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Search for Arthritis in General Medicine
Physician-authored summaries on the latest research on arthritis, editorials on arthritis, and perspectives on arthritis - drawn from the top medical journals.
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Tocilizumab: Interleukin-6 Inhibitor Is Effective in Adult and Juvenile Arthritis
- March 27, 2008
- Bruce Soloway, MD
- General Medicine
Its potential seems greatest as a treatment for juvenile idiopathic arthritis.- Reviewing:
- Smolen JS et al., Lancet 2008 Mar 22; 371:987. Yokota S et al., Lancet 2008 Mar 22; 371:998. Bongartz T., Lancet 2008 Mar 22; 371:961.
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Predicting Progression from Undifferentiated Arthritis to RA
- February 27, 2007
- Allan S. Brett, MD
- General Medicine
A new prediction rule identified which patients with undifferentiated arthritis were most likely to progress to rheumatoid arthritis.- Reviewing:
- van der Helm-vanMil AHM et al., Arthritis Rheum 2007 Feb; 56:433-40.
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Gastrointestinal Risks of Celecoxib vs. Diclofenac-plus-Omeprazole
- July 29, 2010
- Allan S. Brett, MD
- General Medicine
Among arthritis patients, risk for presumed GI bleeding was lower with celecoxib, but concerns remain.- Reviewing:
- Chan FKL et al., Lancet 2010 Jul 17; 376:173.
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Gastroprotection with a New COX-2 Inhibitor: Clinically Significant?
- February 21, 2007
- Bruce Soloway, MD
- General Medicine
In a secondary analysis of results from earlier trials, etoricoxib had little clinical GI benefit over diclofenac.- Reviewing:
- Laine L et al., Lancet 2007 Feb 10; 369:465-73. Drenth JPH and Verheugt FW., Lancet 2007 Feb 10; 369:439-40.
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Change in Bone and Joint Disease E-mail Alert Free
- October 9, 2008
Alberta Fitzpatrick, Publisher, Journal Watch- General Medicine
Dear Readers, -
Rheumatoid Arthritis Linked to Risks for Atrial Fibrillation and Stroke Free
- March 22, 2012
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
Close monitoring of RA patients is warranted.- Reviewing:
- Lindhardsen J et al., BMJ 2012 Mar 8; 344:e1257.
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Should Prednisone Be Added to Methotrexate for Early Rheumatoid Arthritis?
- March 22, 2012
- Jamaluddin Moloo, MD, MPH
- General Medicine
Yes, according to a randomized trial — but with caveats.- Reviewing:
- Bakker MF et al., Ann Intern Med 2012 Mar 6; 156:329.
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Concomitant Septic and Crystal Arthritis
- January 19, 2012
- Allan S. Brett, MD
- General Medicine
In a hospital setting, a small proportion of patients with gout or pseudogout had coexisting septic arthritis.- Reviewing:
- Papanicolas LE et al., J Rheumatol 2012 Jan; 39:157.
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New Classification Criteria for Rheumatoid Arthritis
- September 23, 2010
- Allan S. Brett, MD
- General Medicine
The goal is early identification of patients who can benefit from intervention.
CME Exam- Reviewing:
- Aletaha D et al., Arthritis Rheum 2010 Sep; 62:2569.
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Is the Incidence and Prevalence of Rheumatoid Arthritis Rising Among Women?
- August 17, 2010
- Jonathan S. Coblyn, MD
- General Medicine
Smoking, vitamin D deficiency, and low-estrogen-dose oral contraceptives could be factors.
CME Exam- Reviewing:
- Myasoedova E et al., Arthritis Rheum 2010 Jun; 62:1576.
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Herpes Zoster in Arthritis Patients Who Take Anti-TNF-α Agents
- March 10, 2009
- Thomas L. Schwenk, MD
- General Medicine
- Reviewing:
- Strangfeld A et al., JAMA 2009 Feb 18; 301:737. Whitley RJ and Gnann JW Jr., JAMA 2009 Feb 18; 301:774.
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TNF Antagonists for Treatment of Juvenile Rheumatoid Arthritis
- September 25, 2008
- Deborah M. DeMarco, MD
- General Medicine
In children, adalimumab with or without methotrexate reduced disease activity and number of flares.- Reviewing:
- Lovell DJ et al., N Engl J Med 2008 Aug 21; 359:810.
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Bedtime Dose of Modified-Release Prednisone Reduces Morning Arthritis Stiffness
- February 7, 2008
- Bruce Soloway, MD, and Allan S. Brett, MD
- General Medicine
Modified-release prednisone offered greater relief of morning stiffness and no greater risk than immediate-release prednisone.- Reviewing:
- Buttgereit F et al., Lancet 2008 Jan 19; 371:205.
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Identification of a Molecular Key to Rheumatoid Arthritis
- March 8, 2007
- Anthony L. Komaroff, MD
- General Medicine
New research suggests that a synovial cell molecule is involved in the inflammatory process — and, therefore, may be a target for new therapies.- Reviewing:
- Lee DM et al., Science 2007 Feb 16; 315:1006-10. Firestein GS., Science 2007 Feb 16; 315:952-3.
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Chaperonin 10: Early Evidence of Efficacy in Rheumatoid Arthritis Free
- October 10, 2006
- Bruce Soloway, MD
- General Medicine
This new therapeutic approach might offer relief for patients with treatment-resistant RA.- Reviewing:
- Vanags D et al., Lancet 2006 Sep 2; 368:855-63.
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Lymphoma Risk in Rheumatoid Arthritis
- October 3, 2006
- Deborah M. DeMarco, MD
- General Medicine
Only 0.5% of RA patients developed lymphoma, but risk was markedly increased in patients with high inflammatory disease activity.- Reviewing:
- Baecklund E et al., Arthritis Rheum 2006 Mar; 54:692-701. Weyand CM et al., Arthritis Rheum 2006 Mar; 54:685-9.
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Prednisone for Rheumatoid Arthritis: Radiographic Follow-Up
- May 12, 2006
- Allan S. Brett, MD
- General Medicine
Benefits from low-dose steroid therapy might persist for several years after therapy ends.- Reviewing:
- Jacobs JW et al., Arthritis Rheum 2006 May; 54:1422-8.
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Early Low-Dose Steroids for Rheumatoid Arthritis
- December 23, 2005
- Allan S. Brett, MD
- General Medicine
Low-dose steroids, in conjunction with a DMARD, appear to benefit patients with early-stage RA.- Reviewing:
- Wassenberg S et al., Arthritis Rheum 2005 Nov; 52:3371-80. Svensson B et al., Arthritis Rheum 2005 Nov; 52:3360-70.
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Effective New Treatment in Mouse Models of Lupus and Autoimmune Arthritis
- September 30, 2005
- Anthony L. Komaroff, MD
- General Medicine
A family of cell-signaling molecules, the phosphatidylinositol 3-kinases (PI3K), is important in immune activation and other biological processes. One member of the family, PI3Kγ, has . . .- Reviewing:
- Camps M et al., Nat Med 2005 Sep; 11:936-43. Barber DF et al., Nat Med 2005 Sep; 11:933-5. Ohashi PS and Woodgett JR., Nat Med 2005 Sep; 11:924-5.
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New Drug for Rheumatoid Arthritis
- September 23, 2005
- Allan S. Brett, MD
- General Medicine
Patients with rheumatoid arthritis (RA) often remain symptomatic despite treatment with disease-modifying drugs such as methotrexate and tumor-necrosis–factor inhibitors. Abatacept (Orencia), a new drug that . . .
Audio Interview- Reviewing:
- Genovese MC et al., N Engl J Med 2005 Sep 15; 353:1114-23.
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