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Search for Asthma in General Medicine
Physician-authored summaries on the latest research on asthma, editorials on asthma, and perspectives on asthma - drawn from the top medical journals.
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Perimenstrual Asthma Is Associated with More-Severe Symptoms
- April 23, 2013
- David J. Amrol, MD
- General Medicine
Women whose asthma worsened during menstruation were more likely to be nonallergic.- Reviewing:
- Rao CK et al., Chest 2013 Apr; 143:984.
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Sublingual Immunotherapy Is Effective for Allergic Rhinitis and Asthma
- April 2, 2013
- David J. Amrol, MD
- General Medicine
But U.S. clinicians should wait until the FDA approves these products.- Reviewing:
- Lin SY et al., JAMA 2013 Mar 27; 309:1278. Nelson HS., JAMA 2013 Mar 27; 309:1297.
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Another Look at As-Needed Inhaled Steroids for Asthma
- September 25, 2012
- David J. Amrol, MD
- General Medicine
Daily inhaled steroids might not be needed for all patients with mild-to-moderate asthma, but we shouldn't abandon current guidelines yet.
CME Exam- Reviewing:
- Calhoun WJ et al., JAMA 2012 Sep 12; 308:987. O'Connor GT and Reibman J., JAMA 2012 Sep 12; 308:1036.
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Tiotropium Prevents Exacerbations in Some Patients with Severe Asthma Free
- September 13, 2012
- David J. Amrol, MD
- General Medicine
In patients with poorly controlled asthma, this agent might be a reasonable option.
CME Exam- Reviewing:
- Kerstjens HAM et al., N Engl J Med 2012 Sep 27; 367:1198. Bel EH., N Engl J Med 2012 Sep 27; 367:1257.
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Asthma Defies “One Size Fits All” Diagnosis
- April 3, 2012
- David J. Amrol, MD
- General Medicine
Many patients with mild-to-moderate asthma have persistently noneosinophilic disease.
CME Exam- Reviewing:
- McGrath KW et al., Am J Respir Crit Care Med 2012 Mar 15; 185:612.
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The Placebo Response in Asthma
- July 26, 2011
- Allan S. Brett, MD
- General Medicine
Objective and subjective responses to placebos differed in patients with stable asthma.- Reviewing:
- Wechsler ME et al., N Engl J Med 2011 Jul 14; 365:119. Moerman DE., N Engl J Med 2011 Jul 14; 365:171.
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Greater Role for Leukotriene-Receptor Antagonists in Asthma?
- May 10, 2011
- David J. Amrol, MD
- General Medicine
In real-world practices, these drugs compared favorably with guideline-recommended first-line agents.
CME Exam- Reviewing:
- Price D et al., N Engl J Med 2011 May 5; 364:1695. Dahlén S-E et al., N Engl J Med 2011 May 5; 364:1769.
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Do Inhaled Steroids Raise Pneumonia Risk in Asthma Patients?
- March 17, 2011
- Allan S. Brett, MD
- General Medicine
An industry-sponsored meta-analysis says no.- Reviewing:
- O'Byrne PM et al., Am J Respir Crit Care Med 2011 Mar 1; 183:589.
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Tiotropium for Adults with Uncontrolled Asthma?
- October 7, 2010
- David J. Amrol, MD
- General Medicine
The drug improved symptoms and lung function when added to inhaled corticosteroids.- Reviewing:
- Peters SP et al., N Engl J Med 2010 Sep 19;:
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Another Trial of Proton-Pump Inhibitor Therapy for Asthma
- May 25, 2010
- Allan S. Brett, MD
- General Medicine
Esomeprazole provided no clinically important benefits.- Reviewing:
- Kiljander TO et al., Am J Respir Crit Care Med 2010 May 15; 181:1042.
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Step-Up Therapy for Poorly Controlled Asthma in Children
- March 16, 2010
- Howard Bauchner, MD
- General Medicine
Study results, favoring long-acting ß-agonists, are in tension with a recent FDA advisory.- Reviewing:
- Lemanske RF Jr et al., N Engl J Med 2010 Mar 18; 362:975. von Mutius E and Drazen JM., N Engl J Med 2010 Mar 18; 362:1042.
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No Relation Between Asthma Control and Asymptomatic Acid Reflux
- December 1, 2009
- Allan S. Brett, MD
- General Medicine
Patients do not benefit from searching for silent reflux.- Reviewing:
- DiMango E et al., Am J Respir Crit Care Med 2009 Nov 1; 180:809.
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Are Proton-Pump Inhibitors Beneficial for Patients with Poorly Controlled Asthma? Free
- April 16, 2009
- Allan S. Brett, MD
- General Medicine
For patients with minimal heartburn, probably not- Reviewing:
- The American Lung Association Asthma Clinical Research Centers., N Engl J Med 2009 Apr 9; 360:1487.
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Formal Allergy Assessment in Patients with Rhinitis and Asthma
- April 7, 2009
- Allan S. Brett, MD
- General Medicine
In self-assessments, patients commonly misidentified the allergens that cause them trouble.- Reviewing:
- Smith HE et al., J Allergy Clin Immunol 2009 Mar; 123:646.
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Does Measuring Exhaled Nitric Oxide Improve Asthma Care in Adolescents?
- September 30, 2008
- Howard Bauchner, MD
- General Medicine
Monitoring exhaled nitric oxide did not improve symptoms or lung function in this randomized controlled study.- Reviewing:
- Szefler SJ et al., Lancet 2008 Sep 20; 372:1065.
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Natural History of Asthma
- January 3, 2008
- Howard Bauchner, MD
- General Medicine
Use of health services shortly after diagnosis was the strongest predictor of persistent disease.- Reviewing:
- To T et al., Arch Pediatr Adolesc Med 2007 Dec; 161:1197.
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Exhaled Nitric Oxide — Guidance for Asthma Management?
- August 7, 2007
- Allan S. Brett, MD
- General Medicine
Patients whose steroid dosing was determined by nitric oxide levels did not have better outcomes than those whose dosing followed standard guidelines.- Reviewing:
- Shaw DE et al., Am J Respir Crit Care Med 2007 Aug 1; 176:231-7. Travers J et al., Am J Respir Crit Care Med 2007 Aug 1; 176:238-42.
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Reducing the Intensity of Treatment in Mild Asthma Free
- May 16, 2007
- Allan S. Brett, MD
- General Medicine
Two randomized trials demonstrate the feasibility of step-down therapy in patients whose asthma is well controlled.- Reviewing:
- The American Lung Association Asthma Clinical Research Centers., N Engl J Med 2007 May 17; 356:2027-39. Papi A et al., N Engl J Med 2007 May 17; 356:2040-52.
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Does Home Use of Peak Flow Meters Improve Asthma Management in Adults?
- December 12, 2006
- Allan S. Brett, MD
- General Medicine
Peak flow monitoring did not improve outcomes in patients who were middle-aged and older.- Reviewing:
- Buist AS et al., Am J Respir Crit Care Med 2006 Nov 15; 174:1077-87.
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Preventive Care for Children with Asthma
- November 2, 2006
- Robert Dershewitz, MD, MSc
- General Medicine
Prompting clinicians led to higher rates of preventive care delivery but left considerable room for improvement.- Reviewing:
- Halterman JS et al., Arch Pediatr Adolesc Med 2006 Oct; 160:1018-25.
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