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Physician-authored summaries on the latest research on genetics, editorials on genetics, and perspectives on genetics - drawn from the top medical journals.
You searched for: genetics Items 1 to 20 of 37 results
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GENETICS EVOLVES FROM BASIC SCIENCE TO MEDICAL SPECIALTY.
- December 3, 1993
- THL
Several advances indicating the arrival of molecular medicine are presented in an issue of JAMA devoted to molecular genetics.- Covering:
- Babul R et al., JAMA 1993 Nov 17; 270:
2321 2325 . - MacColin M et al., JAMA 1993 Nov 17; 270:
2316 2320 . - Kaback M et al., JAMA 1993 Nov 17; 270:
2307 2315 .
- Babul R et al., JAMA 1993 Nov 17; 270:
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Genetics, Breast Density, and Breast Cancer
- October 1, 2002
- Allan S. Brett, MD
Results of this twin study demonstrated that genetics play a significant role in development of dense breast tissue.- Covering:
- Boyd NF et al., N Engl J Med 2002 Sep 19; 347:886-94.
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SOLID EVIDENCE THAT GENETICS STRONGLY INFLUENCES BODY WEIGHT.
- May 25, 1990
- ALK
A "nature vs. nurture" controversy has raged with regard to body weight and obesity. In recent years, the evidence that genetics ("nature") is of great . . .- Covering:
- Sims EAH., N Engl J Med 1990 May 24; 322:
1522 1524 . - Stunkard AJ et al., N Engl J Med 1990 May 24; 322:
1483 1487 . - Bouchard C et al., N Engl J Med 1990 May 24; 322:
1477 1482 .
- Sims EAH., N Engl J Med 1990 May 24; 322:
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MicroRNAs Play Central Role in Cancer
- July 8, 2005
- Anthony L. Komaroff, MD
MicroRNAs (miRNAs) are very small RNAs that control the expression of genes by attaching to a specific part of messenger RNA, thereby silencing the messenger . . .- Covering:
- Lu J et al., Nature 2005 Jun 9; 435:834-8.
- He L et al., Nature 2005 Jun 9; 435:828-33.
- O’Donnell KA et al., Nature 2005 Jun 9; 435:839-43.
- Meltzer PS., Nature 2005 Jun 9; 435:745-6.
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Osteoporotic Fractures: Genetics Plays a Minor Role
- December 17, 1999
- KI Marton
There are several well-known modifiable risk factors for osteoporotic fractures, but what role do genetic factors play? To address this question, Finnish investigators performed this . . .- Covering:
- Kannus P et al., BMJ 1999 Nov 20; 319:
1334 1337 .
- Kannus P et al., BMJ 1999 Nov 20; 319:
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Inherited Polymorphism Protects American Blacks from Progressive Heart Failure
- June 12, 2008
- Anthony L. Komaroff, MD
A polymorphism in GRK5 acts as a genetic β-blocker.- Covering:
- Liggett SB et al., Nat Med 2008 May; 14:510.
- Eschenhagen T., Nat Med 2008 May; 14:485.
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What Is the Penetrance of Hereditary Hemochromatosis?Free!
- January 16, 2008
- Allan S. Brett, MD
About one quarter of older men who were homozygous for the HFE C282Y mutation had clinically evident disease.- Covering:
- Allen KJ et al., N Engl J Med 2008 Jan 17; 358:221.
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Possible Genetic Causes for Preterm Birth
- January 2, 2007
- Robert W. Rebar, MD
The risk is linked with genetic polymorphisms.- Covering:
- Murtha AP et al., Am J Obstet Gynecol 2006 Nov; 195:1249-53.
- Engel SM et al., Am J Obstet Gynecol 2006 Nov; 195:1231.e1-11.
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Discovery of Molecule Important in Stem Cell Aging and Cancer
- October 10, 2006
- Anthony L. Komaroff, MD
Studies in mice show that the protein p16INK4a is produced by stem cells in increasing amounts with age, and that it reduces proliferation of those cells.- Covering:
- Janzen V et al., Nature 2006 Sep 6;:
- Molofsky AV et al., Nature 2006 Sep 6;:
- Krishnamurthy J et al., Nature 2006 Sep 6;:
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Certain Gene Mutations Extend Lifespan and Inhibit Tumor Growth
- October 10, 2006
- Anthony L. Komaroff, MD
A study in worms yields a surprising result.- Covering:
- Pinkston JM et al., Science 2006 Aug 18; 313:971-5.
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Polymorphisms in ANP and Its Receptor Are Associated with Increased Left Ventricular Mass
- September 21, 2006
- Kirsten E. Fleischmann, MD, MPH
Genetic factors may help explain cardiac hypertrophy in patients with hypertension.- Covering:
- Rubattu S et al., J Am Coll Cardiol 2006 Aug 1; 48:499-505.
- London B., J Am Coll Cardiol 2006 Aug 1; 48:506-7.
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Two Melanoma-Related Mutations Tend to Occur Together
- July 20, 2006
- Anthony L. Komaroff, MD
These findings demonstrate an association between MC1R and BRAF, each of which increases risk for melanoma.- Covering:
- Landi MT et al., Science 2006 Jun 29;:
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Major Breakthrough in Mapping Disease-Related Genes: The HapMap
- November 4, 2005
- Anthony L. Komaroff, MD
The human genome contains about 10 million single nucleotide polymorphisms (SNPs). Each SNP marks a particular spot on the genome. SNPs are inherited along with . . .- Covering:
- The International HapMap Consortium., Nature 2005 Oct 27; 437:1299-320.
- Goldstein DB and Cavalleri GL., Nature 2005 Oct 27; 437:1241-2.
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ADAM33: A New Asthma Gene
- August 27, 2002
- Anthony L. Komaroff, MD
In a study that joined epidemiology with molecular genetics, a partially industry-sponsored team from the U.S. and U.K. evaluated 460 white sibling-pairs, in which both . . .- Covering:
- Van Eerdewegh P et al., Nature 2002 Jul 25; 418:426-30.
- Drazen JM and Weiss ST., Nature 2002 Jul 25; 418:383-4.
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Tailoring Drug Treatment to Genetics: An Evolving Estrogen Story?
- April 12, 2002
- Robert W. Rebar, MD
To ascertain whether genetic factors affect HDL cholesterol levels, researchers measured the association between sequence polymorphisms in the gene that encodes estrogen receptor α (ER-α) . . .- Covering:
- Herrington DM et al., N Engl J Med 2002 Mar 28; 346:967-74.
- Krauss RM., N Engl J Med 2002 Mar 28; 346:1017-8.
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Subarachnoid Hemorrhage and Genetics
- February 22, 2000
- KI Marton
Several studies have indicated that first-degree relatives of people with subarachnoid hemorrhage (SAH) have an increased risk for suffering SAH themselves. However, nearly all of . . .- Covering:
- Gaist D et al., BMJ 2000 Jan 15; 320:
141 145 .
- Gaist D et al., BMJ 2000 Jan 15; 320:
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DIABETES AND THE GENETICS OF RENAL FAILURE.
- October 1, 1996
- KI Marton
Angiotensin converting enzyme (ACE) inhibition helps slow the progression of renal failure in diabetic patients, perhaps in part because angiotensin II affects hemodynamic mechanisms and . . .- Covering:
- Parving HH et al., BMJ 1996 Sep 7; 313:
591 594 .
- Parving HH et al., BMJ 1996 Sep 7; 313:
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DO GENETICS INFLUENCE SMOKING.
- October 2, 1992
- ALK
Certain addictions, notably alcoholism, are subject to genetic as well as environmental influences. A new study finds a genetic component to cigarette smoking.- Covering:
- Carmelli D et al., N Engl J Med 1992 Sep 17; 327:
829 833 .
- Carmelli D et al., N Engl J Med 1992 Sep 17; 327:
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THE GENETICS OF NON-INSULIN-DEPENDENT DIABETES.
- June 21, 1991
- KIM
The hereditary factors surrounding non-insulin- dependent diabetes mellitus (NIDDM) are still a mystery. While the disease seems to have a familial pattern, no clear-cut pattern . . .- Covering:
- Alcolado JC; Alcolado R., BMJ 1991 May 18; 302:
1178 1180 .
- Alcolado JC; Alcolado R., BMJ 1991 May 18; 302:
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THE GENETICS OF PREMENSTRUAL SYNDROME.
- November 20, 1987
- HGA
To determine whether there is a genetic component to premenstrual syndrome (PMS), Dalton and colleagues studied the prevalence of PMS in 15 pairs of monozygotic . . .- Covering:
- Dalton K; Dalton M E; Guthrie K., BMJ 1987 Oct 24; 295:
1027 1028 .
- Dalton K; Dalton M E; Guthrie K., BMJ 1987 Oct 24; 295:
You searched for: genetics Items 1 to 20 of 37 results