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Search for Thrombocytopenia in General Medicine
Physician-authored summaries on the latest research on thrombocytopenia, editorials on thrombocytopenia, and perspectives on thrombocytopenia - drawn from the top medical journals.
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You searched for: thrombocytopenia in General Medicine
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A New Investigational Drug for Treatment of Thrombocytopenia
- December 27, 2007
- Allan S. Brett, MD
- General Medicine
In two trials, eltrombopag showed promise as thrombocytopenia treatment.- Reviewing:
- Bussel JB et al., N Engl J Med 2007 Nov 29; 357:2237. McHutchison JG et al., N Engl J Med 2007 Nov 29; 357:2227.
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It's Confirmed: Vancomycin Causes Immune Thrombocytopenia
- March 13, 2007
- Abigail Zuger, MD
- General Medicine
Serious clinical sequelae may result.- Reviewing:
- Von Drygalski A et al., N Engl J Med 2007 Mar 1; 356:904-10. Warkentin TE., N Engl J Med 2007 Mar 1; 356:891-3.
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Autologous Cryopreserved Platelets for Treating Thrombocytopenia
- August 6, 2002
- Sir Brian Jarman, PhD, FRCP, FRCGP, FFPHM, FMedSci
- General Medicine
During the past 20 years, platelet transfusions have been used increasingly in patients who undergo intensive myelosuppressive therapy. Due to concerns about alloimmunization-related risks, attempts . . .- Reviewing:
- Vadhan-Raj S et al., Lancet 2002 Jun 22; 359:2145-52.
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Heparin-Induced Thrombocytopenia as a Cause of Thromboembolism in Outpatients
- March 8, 2002
- Richard Saitz, MD, MPH
- General Medicine
The diagnosis of heparin-induced thrombocytopenia usually is considered when platelet counts drop during the first 2 weeks of heparin therapy. Investigators now report on a . . .- Reviewing:
- Rice L et al., Ann Intern Med 2002 Feb 5; 136:210-15.
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Time Course of Heparin-Induced Thrombocytopenia
- May 4, 2001
- AS Brett
- General Medicine
Some heparin recipients develop thrombocytopenia, which is caused by IgG antibodies against complexes of platelet factor 4 and heparin. These Canadian researchers describe the time . . .- Reviewing:
- Warkentin TE and Kelton JG., N Engl J Med 2001 Apr 26; 344:
1286 1292 .
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NO THROMBOCYTOPENIA WITH LOW-MOLECULAR-WEIGHT HEPARIN.
- May 23, 1995
- AS Brett
- General Medicine
Heparin-induced thrombocytopenia paradoxically predisposes patients to thrombotic complications. To assess the frequency of this problem, Canadian researchers followed daily platelet counts in 665 patients who . . .- Reviewing:
- Warkentin TE, et al., N Engl J Med 1995 May 18; 332:
1330 1335 .
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SPLENIC IRRADIATION FOR IMMUNE THROMBOCYTOPENIA.
- June 30, 1992
- ASB
- General Medicine
First-line treatment for immune thrombocytopenia includes corticosteroids, splenectomy, or both. However, each of these therapies carries risks that are particularly problematic in elderly or chronically . . .- Reviewing:
- Calverly DC et al., Ann Intern Med 1992 Jun 15; 116:
977 981 .
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Rituximab for Idiopathic Thrombocytopenic Purpura?
- March 8, 2007
- Deborah M. DeMarco, MD
- General Medicine
In the absence of randomized, controlled trials, clinicians should be very cautious about using rituximab for this or any other autoimmune condition.- Reviewing:
- Arnold DM et al., Ann Intern Med 2007 Jan 2; 146:25-33.
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Oral Thrombopoietin Receptor Agonist Raises Platelet Count in ITP
- March 10, 2009
- Bruce Soloway, MD
- General Medicine
In addition, bleeding was less common with eltrombopag.- Reviewing:
- Bussel JB et al., Lancet 2009 Feb 21; 373:641.
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Romiplostim: A New Approach for ITP?
- February 26, 2008
- Bruce Soloway, MD
- General Medicine
A therapeutic protein that raises platelet counts, rather than prevents platelet destruction, could hold promise in treating this autoimmune disorder.- Reviewing:
- Kuter DJ et al., Lancet 2008 Feb 2; 371:395.
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ZIDOVUDINE FOR HIV-RELATED THROMBOCYTOPENIA.
- March 21, 1989
- ASB
- General Medicine
Immune thrombocytopenic purpura is a well-recognized complication of human immunodeficiency virus (HIV) infection, although the exact mechanism of platelet destruction is unknown. These researchers postulated . . .- Reviewing:
- Oksenhendler E et al., Ann Intern Med 1989 Mar; 110:
365 368 .
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“DRESS”— A Case Series
- January 25, 2011
- Allan S. Brett, MD
- General Medicine
Drug reaction with eosinophilia and systemic symptoms usually occurs several weeks after the culprit drug is started.- Reviewing:
- Chen Y-C et al., Arch Dermatol 2010 Dec; 146:1373.
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Long-Term Clinical and Immunological Effects of Anti-CD20 Treatment in Refractory SLE
- June 24, 2008
- Deborah M. DeMarco, MD
- General Medicine
Anti-CD20 treatment could be beneficial for treatment of patients with refractory lupus nephritis and autoimmune cytopenias.- Reviewing:
- Lindholm C et al., J Rheumatol 2008 May; 35:826.
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Myelodysplastic Syndromes: Incidence and Survival
- April 26, 2007
- Allan S. Brett, MD
- General Medicine
Data from a U.S. cancer surveillance program indicate an incidence of about 3.5 cases per 100,000 per year.- Reviewing:
- Ma X et al., Cancer 2007 Apr 15; 109:1536-42.
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A Noninvasive Way to Identify Esophageal Varices?
- December 13, 2006
- Allan S. Brett, MD
- General Medicine
Patients at low risk had high ratios of platelet count to bipolar spleen diameter.- Reviewing:
- Giannini EG et al., Am J Gastroenterol 2006 Nov; 101:2511-9.
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Safety and Efficacy of LMW Heparin in Older or Obese Patients
- March 11, 2005
- Jamaluddin Moloo, MD, MPH
- General Medicine
Fixed-dose, low-molecular-weight (LMW) heparins are used routinely to prevent venous thromboembolism (VTE). However, such regimens could be less effective in obese patients and could be . . .- Reviewing:
- Kucher N et al., Arch Intern Med 2005 Feb 14; 165:341-5.
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Risk for Intracranial Hemorrhage Among Warfarin Users with Atrial Fibrillation
- December 21, 2004
- Richard Saitz, MD, MPH, FACP, FASAM
- General Medicine
Which INR levels and patient characteristics are most likely to confer risk?- Reviewing:
- Fang MC et al., Ann Intern Med 2004 Nov 16; 141:745-52.
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Gaucher Disease Usually Does Not Complicate Pregnancy
- March 30, 2004
- Robert W. Rebar, MD
- General Medicine
As the most common glycolipid storage disorder, Gaucher disease does turn up in women of reproductive age. How do affected women fare in pregnancy? Researchers . . .- Reviewing:
- Elstein Y et al., Am J Obstet Gynecol 2004 Feb; 190:435-41.
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THE SARS EPIDEMIC
- December 31, 2003
- General Medicine
No sooner did bioterrorism fade from the headlines last year than an infectious-disease natural catastrophe took its place. At last count, more than 8000 people . . . -
Short-Course, High-Dose Steroids for ITP
- September 12, 2003
- Allan S. Brett, MD
- General Medicine
High-dose dexamethasone therapy led to rapid platelet count increases in many patients.- Reviewing:
- Cheng Y et al., N Engl J Med 2003 Aug 28; 349:831-6. George JN and Vesely SK., N Engl J Med 2003 Aug 28; 349:903-5.
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