Reader Remarks on:

Comparison of Three Insulin Regimens

The management of type II diabetes
Reason to use biphasic insulins

The management of type II diabetes

Bruce A. Kottke MD,PHD, FACC, Clark and Daughtrey LLP, 16 Nov 2009 8:34 PM EST

Competing interests: None declared

If in the basal group, sulfonoureas had been elinated and TZDs used with metformin instead, and Januvia or Onglyza used instead of postprandial insulin the control would have been much better and the incidence of hypoglycemia markedly reduced. In this day and age there is little justification for the use of biphasic insulins in type II diabetes.

Reason to use biphasic insulins

Gil Holmes, MD, 1 Dec 2009 8:17 PM EST

Competing interests: None declared

I agree that medically there is little indication for biphasic insulins. But in the real world, finances sometimes are more important than the actual medicine. And the biphasics are generally cheaper and you can get away with only two shots a day.

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