Reader Remarks on:

Bupropion plus Naltrexone for Weight Loss?

Bupropion/Naltrexone study drop-out rate
Bupropion/Naltrexone study drop-out rate
Withdraw maybe disease specific

Bupropion/Naltrexone study drop-out rate

Anthony K. Rice, Martinsburg WV, 3 Sep 2010 12:20 PM EST

Competing interests: None declared

The participant withdrawal rate seems high. I wonder if this was a result of some unmentioned factor in the study design or population. It doesn't seem to be related to the study medication, since the rate in the placebo arm was similar.

Also, the loss of half the study subjects must negatively impact the power of the study to detect less common adverse effects, even though it was apparently still adequately powered to show a significant weight loss benefit over placebo.

Bupropion/Naltrexone study drop-out rate

Rachel G Sagar, 27 Sep 2010 11:36 PM EST

Competing interests: None declared

Maybe the ones who were feeling really ill from side effects withdrew! Why else would you withdraw from a study?

Withdraw maybe disease specific

Rogerio L Coelho, Family Practice - Curitiba Municipal Health System - Brasil, 2 Oct 2010 3:50 PM EST

Competing interests: None declared

Why indeed? And why do people quit tehir diets? And why do peple stop their excercise? And why do people let their weight go astray and cannot even get out of bed?

The Obesity pandemic is a multifactoral, psico-social-genetic phenomenon, it is obvious that obese overeat (the weight keeps on adding) and they continue to do so.

Anyone who treats these patients knows that even the best combination of drugs / diets / excercise will have a major dropout ... what we need is to know WHY this happens, and if we can do anything about it.

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